off-target effects

Cross-Priming and Cross-Tolerance After Intramuscular mRNA Vaccination for Viral Infections: Feasibility and Implications

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By Siguna Mueller Center for Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy Life2025, 15(10), 1575; https://doi.org/10.3390/life15101575 Abstract The induction of robust CD8 T cell immunity after intramuscular (i.m.) mRNA vaccination has remained a challenge. Due to the limited presence of professional antigen-presenting cells (APCs) in muscle tissue, this route of administration tends … Read more

Book Review: Programming Evolution: A Crack in Science

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Giuseppe Longo reviews the book “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution” by Nobel Prize winner, Jennifer Doudna, and Samuel Sternberg Abstract: Nobel Prize winner, Jennifer Doudna, and Samuel Sternberg survey recent advances in a pioneering area of molecular biology. In an accessible and elegant style, the authors present … Read more